Our research areas
We develop novel methodologies at the intersection of structural biology, artificial intelligence, and clinical medicine.
Structural alphabets
25+ years of developing Protein Blocks and Protein Units, our foundational methods that encode 3D structures into powerful 1D representations for sequence-structure analysis.
learn more →AI & protein flexibility
PEGASUS, MEDUSA & PYTHIA use Protein Language Model embeddings to predict flexibility, local structure, and dynamics, replacing weeks of simulation in seconds.
learn more →Molecular dynamics
The ATLAS database provides standardized MD simulations for 1,900+ proteins. We specialize in membrane proteins, transporters (GluT1), and ion channels.
learn more →Translational bioinformatics
From transfusion medicine and blood group antigens to nanobody engineering and glycobiology, our specialized databases power real clinical applications.
learn more →Bridging computation and clinical medicine
DSIMB is a team within the BIGR unit (Biologie Intégrée du Globule Rouge). We develop computational algorithms and apply them to red blood cell pathologies.
Under the tutelage of INSERM, Université Paris Cité, and EFS as part of the InIdex GR-Ex, we challenge the view of the RBC as a simple "hemoglobin bag", instead studying it as a complex system involved in immune defense, vascular regulation, and signaling.
- Structural bioinformatics, from sequence to 3D structure
- Molecular simulations, exploring protein dynamics
- Deep learning, predictive and generative AI
- Translational research, from bench to bedside
Our tools
ATLAS
The Atlas of protein molecular dynamics. Standardized MD simulations for 1,938+ proteins with interactive analysis tools.
SWORD2
Protein structure domain partitioning. Automatically identifies protein domains using hierarchical clustering and Protein Units.
PEGASUS
Predict molecular dynamics flexibility (RMSF, Phi/Psi angles, LDDT) using protein language models.
Institutional ecosystem
Our network spans Paris and the Indian Ocean, enabling research on diverse genetic populations.
European Regional Development Fund
The European Regional Development Fund (ERDF) operates as part of the Economic, Social and Territorial Cohesion Policy. It aims to strengthen economic and social cohesion in the European Union by correcting imbalances between its regions. In France, the ERDF allocation is 9.5 billion euros for the 2014-2020 programming period.
