5VKM (resolution: 2.20 Å)

ID Name Organism Chains bound to carbohydrates
1 B-cell receptor CD22
P20273 (CD22_HUMAN)
Unilectin fold: b-sandwich / Ig-like
Unilectin class: I-type lectin
Unilectin family: Siglec-2 CD22
Homo sapiens 1 chain bound to carbohydrates
Chain A:
2 binding sites
1 glycosylation head interface
4 glycosylation body interfaces
1 N-glycosylation

Chain properties


Carbohydrates


ID Description N° of binding sites Bound to chains Binding affinity
2 α-D-mannopyranose-(1-3)-[α-D-mannopyranose-(1-6)]β-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-β-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-β-D-glucopyranose 5 (1 molecule) A
3 N-acetyl-α-neuraminic acid-(2-6)-β-D-galactopyranose 2 (1 molecule) A -logKd/Ki=3.55, Kd=281uM (PDBbind-CN)

Binding sites


Related structures


Bound to carbohydrates