4KRM (resolution: 2.65 Å)

ID Name Organism Chains bound to carbohydrates
1 Epidermal growth factor receptor
P00533 (EGFR_HUMAN)
Homo sapiens 6 chains bound to carbohydrates
Chain A:
3 glycosylation head interfaces
3 glycosylation body interfaces
3 N-glycosylations
Chain C:
3 glycosylation head interfaces
4 glycosylation body interfaces
3 N-glycosylations
Chain E:
3 glycosylation head interfaces
3 glycosylation body interfaces
3 N-glycosylations
Chain G:
3 glycosylation head interfaces
3 glycosylation body interfaces
3 N-glycosylations
Chain I:
3 glycosylation head interfaces
3 glycosylation body interfaces
3 N-glycosylations
Chain K:
3 glycosylation head interfaces
3 glycosylation body interfaces
3 N-glycosylations
2 Nanobody/VHH domain 7D12
Heavy chain subclass: IGHV1
Lama glama 6 chains bound to carbohydrates
Chain B:
1 glycosylation head interface
1 glycosylation body interface
Chain D:
2 glycosylation head interfaces
1 glycosylation body interface
Chain F:
1 glycosylation head interface
1 glycosylation body interface
Chain H:
2 glycosylation head interfaces
1 glycosylation body interface
Chain J:
1 glycosylation head interface
1 glycosylation body interface
Chain L:
1 glycosylation head interface
1 glycosylation body interface

Chain properties


Carbohydrates


ID Common name Description N° of binding sites Bound to chains
3 α-D-mannopyranose-(1-3)-β-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-β-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-β-D-glucopyranose 24 (6 molecules) A, B, C, D, E, F, G, H, I, J, K, L
4 il-7racdw127 2-acetamido-2-deoxy-β-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-β-D-glucopyranose 2 (1 molecule) C, D
5 zn-α-2-glycoprotein zag 2-acetamido-2-deoxy-β-D-glucopyranose 11 (11 molecules) A, B, C, E, F, G, H, I, J, K, L

Binding sites


Related structures